Microsoft's Diagnostic AI Outscored Doctors on Complex Cases

Microsoft's MAI-DxO, a panel of GPT-5 models, correctly diagnosed 83% of 304 complex cases from the New England Journal of Medicine, against 22% for physicians relying on their own knowledge and about 24% with resources. On emergency cases it scored 80% against 47% for doctors, at roughly $1,300 a case versus $4,700 and up. The results come from text-based simulations in a paper in Science rather than a hospital deployment, and Microsoft is now evaluating the system in hospitals with Beth Israel Deaconess.