An AI Trained on SuperAgers Flags Alzheimer's Risk Years Early

Researchers built an AI model called ARC from brain scans of SuperAgers, people in their 80s with the memory of 50-year-olds, and Alzheimer's patients. Tested on more than 1,300 cognitively unimpaired adults, scores resembling Alzheimer's predicted faster decline, amyloid buildup and conversion over five to 15 years, with an AUC of 0.85. The work is published in Science Advances and remains a research-stage risk model, not a clinical test.